环指蛋白调节蛋白激酶C蛋白抗体
规格：1mg/1ml
英文名： TRIM41
别名： RINCK; RING finger protein that interacts with C kinase; Trim41; Tripartite motif containing 41; TRI41_HUMAN.
分子量： 72kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRIM41
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：细胞核 细胞浆
环指蛋白调节蛋白激酶C蛋白抗体产品介绍：background: Tripartite motif-containing protein 41 (TRIM41), also known as RINCK, is a 630 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Localized to both the nucleus and cytoplasm, TRIM41 associates with protein kinase C (PKC) through the C1A domain of PKC. Studies have shown that overexpression of TRIM41 reduces the levels of PKC in cells, whereas knockdown of TRIM41 leads to increased levels of PKC. Thus, it is hypothesized that TRIM41 plays a role in regulating PCK levels in cells, specifically through the ubiquitination of PKC. Four isoforms of TRIM41 exist as a result of alternative splicing events. Function: Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation 环指蛋白调节蛋白激酶C蛋白抗体of protein kinase C. Subunit: Interacts with PRKCA. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed in multiple tissues with the highest levels in heart and skeletal muscle. Post-translational modifications: Auto-ubiquitinated. Similarity: Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger. Gene ID: 环指蛋白调节蛋白激酶C蛋白抗体90933 Database links: Entrez Gene: 90933 Human Entrez Gene: 211007 Mouse Entrez Gene: 303088 Rat Omim: 610530 Human SwissProt: Q8WV44 Human SwissProt: Q5NCC3 Mouse Unigene: 441488 Human Unigene: 794 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白调节蛋白激酶C蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid