β淀粉样蛋白胞内结构域相关蛋白1抗体
规格：1mg/1ml
英文名： ANKS1B
别名： AIDA 1; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; Anks1b; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; ANS1B_HUMAN; E2A-PBX1-associated protein; E
分子量： 138kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ANKS1B/A
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆 细胞膜 细胞外基质
β淀粉样蛋白胞内结构域相关蛋白1抗体产品介绍：background: The β-Amyloid protein precursor (AbPP) is a widely expressed transmembrane protein that is processed into the b-Amyloid (Ab) peptide, which accumulates in insoluble plaques in the brain of Alzheimer’s disease patients and AbPP intracellular domain (AID). AID may function as a pro-apoptotic peptide, a regulator of calcium homeostasis and a molecule involved in transcriptional regulation. The AID associated protein 1 (AIDA-1) is highly expressed in the brain and is regulated by AbPP. It interacts with AbPP to play a role in brain development. AIDA-1 also interacts with coilin in Cajal bodies to regulate pre-mRNA splicing. Function: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. Subunit: Isoform 3 interacts with DLG4. Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interactsβ淀粉样蛋白胞内结构域相关蛋白1抗体 with EPHA8. Subcellular Location: Cytoplasm; Nucleus; Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed. Tissue Specificity: Highly expressed in marrow from patients with β淀粉样蛋白胞内结构域相关蛋白1抗体pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines. Post-translational modifications: Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage (By similarity). Similarity: Contains 7 ANK repeats. Contains 1 PID domain. Contains 2 SAM (sterile alpha motif) domains. Gene ID: 56899 Database links: Entrez Gene: 56899 Human Omim: 607815 Human SwissProt: Q7Z6G8 Human Unigene: 506458 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
β淀粉样蛋白胞内结构域相关蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid