缺氧诱导基因1蛋白/HIGD1A抗体
规格：1mg/1ml
英文名： HIG1/HIGD1A
别名： Hig1; HIG1 domain family member 1A; HIG1 domain family, member 1A; HIG1 hypoxia inducible domain family, member 1A; HIG1A_HUMAN; HIGD1A; HIMP1; Hypoxia-inducible gene 1 protein.
分子量： 10kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HIG1/HIG
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞浆 细胞膜
缺氧诱导基因1蛋白/HIGD1A抗体产品介绍：background: HIGD1A (HIG1 domain family member 1A), also known as HIG1 (hypoxia-inducible gene 1 protein) or HSPC010, is a 93 amino acid multi-pass membrane protein that contains one HIG1 domain. Existing as two alternatively spliced isoforms, the gene encoding HIGD1A maps to human chromosome 3, which contains approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau 缺氧诱导基因1蛋白/HIGD1A抗体syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. Function: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. Subunit: Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respratory 缺氧诱导基因1蛋白/HIGD1A抗体chain supercomplexes. Subcellular Location: Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane (Probable). Similarity: Contains 1 HIG1 domain. Database links: Entrez Gene: 25994 Human Entrez Gene: 56295 Mouse Entrez Gene: 140937 Rat SwissProt: Q9Y241 Human SwissProt: Q9JLR9 Mouse SwissProt: Q8VH49 Rat Unigene: 593134 Human Unigene: 728813 Human Unigene: 7917 Human Unigene: 347915 Mouse Unigene: 2084 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
缺氧诱导基因1蛋白/HIGD1A抗体产品应用：ELISA=1:500-1000 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid