“冷”蛋白TRPM8抗体
规格：1mg/1ml
英文名： TRPM8
别名： LTrpC-6; LTrpC6 antibody Short form of the TRPM8 cationic channel; Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; Trp p8; Trp-p8; Trpm8; TRPM8_HUMAN
分子量： 128kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRPM8
交叉反应：Human, Mouse, Rat, Dog, Sheep,
细胞定位：细胞膜
“冷”蛋白TRPM8抗体产品介绍：background: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being “冷”蛋白TRPM8抗体activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Subunit: Homotetramer (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein (Probable). Tissue Specificity: Expressed in prostate. Also“冷”蛋白TRPM8抗体 expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors. Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 ub-subfamily. Database links: Entrez Gene: 79054 Human Entrez Gene: 171382 Mouse Entrez Gene: 171384 Rat Omim: 606678 Human SwissProt: Q7Z2W7 Human SwissProt: Q8R4D5 Mouse SwissProt: Q8R455 Rat Unigene: 366053 Human Unigene: 218753 Mouse Unigene: 81225 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TRPM8与感应热和辣的蛋白质属于同一家族，它存在于特定神经细胞的细胞膜上，成为响应外界信号的开关通道。科学家研究发现，当温度低于27摄氏度或者醇存在的条件下，TRPM8通道都会打开，使钙离子等带正电的粒子进入细胞。 TRPM8的蛋白质在产生冷知觉的过程中起着主导作用，并且控制着低温对机体疼痛的缓解效果, TRPM8故称是“冷”蛋白。
“冷”蛋白TRPM8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid