SAMD9蛋白抗体
规格：1mg/1ml
英文名： SAMD9
别名： SAM domain-containing protein 9; SAMD9; SAMD9_HUMAN; sterile alpha motif domain containing 9; Sterile alpha motif domain-containing protein 9; C7orf5.
分子量： 184kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAMD9
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞浆
SAMD9蛋白抗体产品介绍：background: Defects in SAMD9 are the cause of normophosphatemic familial tumoral calcinosis (NFTC). NFTC is an uncommon life-threatening disorder characterized by massive periarticular, and seldom visceral, deposition of calcified tumors. Function: May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. Subunit: Interacts with RGL2. Subcellular Location: Cytoplasm Tissue Specificity: Widely expressed. Very low levels in skeletal muscle. Not detected in fetal brain. Down-regulated in aggressive fibromatosis, as well as in breast and colon cancers. DISEASE: Defects in SAMD9 are the cause of tumoral calcinosis, normophosphatemic, familial (NFTC)SAMD9蛋白抗体 [MIM:610455]. An uncommon disorder characterized by progressive deposition of calcified masses in cutaneous and subcutaneous tissues. Serum phosphate levels are normal. Clinical features include painful calcified ulcerative lesions, massive calcium deposition in the mid- and lower dermis, severe skin and bone infections, erythematous papular skin eruption in infancy, conjunctivitis, and gingivitis. NFTC shows a striking SAMD9蛋白抗体esemblance to acquired dystrophic calcinosis, in which tissue calcification occurs as a consequence of tissue injury/inflammation. Similarity: Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 54809 Human Omim: 610456 Human SwissProt: Q5K651 Human Unigene: 65641 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SAMD9蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid