猫眼综合征染色体候选基因1抗体
规格：1mg/1ml
英文名： CECR1
别名： ADGF; Cat eye syndrome chromosome region candidate 1; Cat eye syndrome critical region protein 1; Cat eye syndrome critical region protein 1 precursor; CECR 1; IDGFL; CECR1_HUMAN.
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CECR1/AD
交叉反应：Human, Pig,
细胞定位：分泌型蛋白
猫眼综合征染色体候选基因1抗体产品介绍：background: CECR1 is a member of the adenosine and AMP deaminases family. It may act as a growth factor and have adenosine deaminase activity. It is a candidate gene for cat eye syndrome. Two transcript variants encoding distinct isoforms have been identified for this gene. Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are猫眼综合征染色体候选基因1抗体widely expressed. Specifically, CECR1 has the highest expression in ***** heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects. Function: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Subunit: Homodimer. Interacts with adenosine receptors. Binds heparin. Subcellular Location: Secreted Tissue Specificity: Detected in blood plasma (at protein level). Widely expressed, with most abundant expression in human ***** heart,猫眼综合征染色体候选基因1抗体 lung, lymphoblasts, and placenta as well as fetal lung, liver, and kidney. In embryo, expressed in the outflow tract and atrium of the developing heart, the VII/VIII cranial nerve ganglion, and the notochord. Similarity: Belongs to the adenosine and AMP deaminases family. ADGF subfamily. Database links: Entrez Gene: 51816 Human Omim: 607575 Human SwissProt: Q9NZK5 Human Unigene: 170310 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
猫眼综合征染色体候选基因1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid