鸟嘌呤核苷酸交换因子抗体
规格：1mg/1ml
英文名： RCBTB1
别名： Chronic lymphocytic leukemia deletion region gene 7 protein; CLL deletion region gene 7 protein; CLLD7; CLLL7 protein; Guanine nucleotide exchange factor; broad-complex, tramtrack and bric a brac; Hyp
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RCBTB1/C
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
鸟嘌呤核苷酸交换因子抗体产品介绍：background: The BTB domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. RCBTB1 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1), also known as GLP, CLLD7, CLLL7 or E4.5, is a 531 amino acid protein that localizes to the nucleus and contains two BTB (POZ) domains and six RCC1 repeats. Expressed ubiquitously, RCBTB1 is thought to be involved in cell cycle regulation, specifically via chromatin remodeling. The gene encoding RCBTB1 maps to a region on human chromosome 13 that 鸟嘌呤核苷酸交换因子抗体is frequently deleted in B-cell chronic lymphocytic leukemia, suggesting a possible role for RCBTB1 in tumor suppression. Function: May be involved in cell cycle regulation by chromatin remodeling. Subcellular Location: Nucleus (Potential). Tissue Specificity: Ubiquitously expressed Similarity: Contains 2 BTB (POZ) domains. Contains 6 RCC1 repeats. Database links: Entrez Gene: 785222 Cow Entrez Gene: 55213 Human鸟嘌呤核苷酸交换因子抗体 Entrez Gene: 71330 Mouse Entrez Gene: 361050 Rat Omim: 607867 Human SwissProt: Q8NDN9 Human SwissProt: Q6NXM2 Mouse Unigene: 508021 Human Unigene: 234195 Mouse Unigene: 229110 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鸟嘌呤核苷酸交换因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid