双氧化酶激活因子2抗体
规格：1mg/1ml
英文名： DUOXA2
别名： Dual oxidase activator 2; Dual oxidase maturation factor 2; SIMNIPHOM; TDH5; DOXA2_HUMAN; Dual oxidase maturation factor-2; Dual oxidase activator 2..
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DUOXA2
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
双氧化酶激活因子2抗体产品介绍：background: DUOXA2 is a 320 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum (ER) and belongs to the DUOXA family. Expressed specifically in thyroid and salivary glands, DUOXA2 is essential for the maturation and transport of DUOX2 from the ER to the plasma membrane and is also thought to play a role in the synthesis of thyroid hormone (TH). Defects in the DUOXA2 gene are associated with the pathogenesis of congenital hypothyroidism, a disorder that affects infants and is characterized by a significant decrease or a complete deficiency of TH from birth. The gene encoding DUOXA2 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease双氧化酶激活因子2抗体 and Marfan syndrome are all associated with defects in chromosome 15-localized genes. Function: Function: Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Specifically 双氧化酶激活因子2抗体expressed in thyroid. Also detected in salivary glands. [PTM] N-glycosylated. DISEASE: Defects in DUOXA2 are the cause of thyroid dyshormonogenesis 5 (TDH5) [MIM:274900]. A disorder due to thyroid dyshormonogenesis, causing hypothyroidism, goiter, and variable mental deficits derived from unrecognized and untreated hypothyroidism Similarity: Belongs to the DUOXA family. Database links: UniProtKB/Swiss-Prot: Q1HG44.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
双氧化酶激活因子2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid