铁调节蛋白/铁调素抗体
规格：1mg/1ml
英文名： Hepcidin-25
别名： Hamp; HEPC; HEPC_RAT; HEPC_MOUSE; Hepc20; Hepc25; HEPCIDIN; Hepcidin; Hepcidin 20; Hepcidin 25; Hepcidin antimicrobial peptide; Hepcidin-20; Hepcidin25; HFE2; HFE2B; LEAP 1; LEAP-1; LEAP1; Liver expre
分子量： 2kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from rat Hepcidin
交叉反应：Mouse, Rat,
细胞定位：分泌型蛋白
铁调节蛋白/铁调素抗体产品介绍：background: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]. Subcellular Location: Secreted. Tissue Specificity: Highest expression in liver and to a lesser extent in铁调节蛋白/铁调素抗体 heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine. DISEASE: Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:613313]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis,铁调节蛋白/铁调素抗体 arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Similarity: Belongs to the hepcidin family. Gene ID: 84604 Database links: Entrez Gene: 57817 Human Entrez Gene: 84506 Mouse Entrez Gene: 84604 Rat Omim: 606464 Human SwissProt: P81172 Human SwissProt: Q9EQ21 Mouse SwissProt: Q99MH3 Rat Unigene: 8821 Human Unigene: 7865 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
铁调节蛋白/铁调素抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid