剪切和多聚腺苷酸化特异性因子5抗体
规格：1mg/1ml
英文名： NUDT21
别名： CFIM 25; CFIM25; Cleavage and polyadenylation specific factor 5 25 kD subunit; Cleavage and polyadenylation specific factor 5 25 kDa; Cleavage and polyadenylation specific factor 5; Cleavage and polya
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NUDT21
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞核
剪切和多聚腺苷酸化特异性因子5抗体产品介绍：background: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008] Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have 剪切和多聚腺苷酸化特异性因子5抗体a role in mRNA export. Subcellular Location: Nucleus. In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. Post-translational modifications: Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2. Similarity: Belongs to the Nudix hydrolase family. CPSF5 subfamily. Contains 1 nudix hydrolase domain. Gene ID: 11051 Database links: Entrez 剪切和多聚腺苷酸化特异性因子5抗体Gene: 11051 Human Entrez Gene: 68219 Mouse Entrez Gene: 291877 Rat Entrez Gene: 394092 Zebrafish Omim: 604978 Human SwissProt: Q3ZCA2 Cow SwissProt: O43809 Human SwissProt: Q9CQF3 Mouse SwissProt: Q4KM65 Rat SwissProt: Q7T3C6 Zebrafish Unigene: 528834 Human Unigene: 354445 Mouse Unigene: 432611 Mouse Unigene: 199052 Rat Unigene: 80520 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
剪切和多聚腺苷酸化特异性因子5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid