d-myc蛋白抗体
规格：1mg/1ml
英文名： d-myc
别名： dMyc1; MYC_DROME; Myc protein; d-Myc1; d-myc.
分子量： 79kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from fruit fly d-my
交叉反应：Firefly, fruit fly
细胞定位：细胞核
d-myc蛋白抗体产品介绍：background: Drosophila melanogaster is a proven and effective model for studying developmental and cellular processes common to higher eukaryotes. Approximately 13,600 genes have been elucidated from more than 120 megabases of euchromatin, and they are organized among the chromosomes 2, 3, 4, X and Y, with the Y chromosome being predominately heterochromatic (1). Drosophila genes can be categorized based on the type of protein they encode and are represented by six major classifications, which include intracellular signaling proteins, transmembrane proteins, RNA binding proteins, secreted factors, transcription regulators (basic helix-loop-helix, homeodomain containing, zinc finger containing, and chromatin associated) or other functional proteins (2). Many of the proteins in Drosophila are structurally and functionally similar across species, as are the pathways involved in transducing intracellular signaling. Among these proteins, myc (d-myc, dmyc1) is a transcription factor that links patterning signals to cell division by regulating events coordinating cellular growth and metabolism (3-7). Function: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes thed-myc蛋白抗体 core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Inhibits the demethylase activity of Lid. Subunit: Heterodimer with another bHLH proteins. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with Max. Interacts with lid. Part of a complex containing lid, dm and ash2. Component of a complex with pont and rept. Subcellular Location: Nucleus. Tissue Specificity: Low levels detected throughout embryo before cellular blastoderm formation, particularly concentrated in pole plasm. Zygotic expression detected during cellular blastoderm stage in endodermal anlagen of anterior and posterior midgut at both poles. After gastrulation, expression detected in invaginating ventral furrow of mesoderm. Continued expression in anterior and posterior midgut and d-myc蛋白抗体mesoderm during germband extension. During late germ-band retraction, expression remains detectable in fusing midgut and presumed developing somatic musculature. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
d-myc蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid