磷酸化细胞信号转导分子SMAD2/SMAD3抗体
规格：1mg/1ml
英文名： phospho-Smad2/Smad3 (Thr8)
别名： Smad2 + Smad3 (phospho T8); p-Smad2 + Smad3 (phospho T8); P-Smad2 /3 (phospho T8); hMAD 2; hMAD 3; hSMAD2; hSMAD3; Mad related protein 2; MADH2; MADH3; MADR2; Mothers against DPP homolog 2; Mothers ag
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞核 细胞浆
磷酸化细胞信号转导分子SMAD2/SMAD3抗体产品介绍：background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this磷酸化细胞信号转导分子SMAD2/SMAD3抗体 gene. [provided by RefSeq, May 2012] Function: SMAD is a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. They mediate the signal of the transforming growth factor (TGF)-beta, and thus regulate multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. Subcellular Location: Cytoplasm. Nucleus. Note:磷酸化细胞信号转导分子SMAD2/SMAD3抗体 Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Gene ID: 4087 Database links: Entrez Gene: 4087 Human Entrez Gene: 4088 Human Entrez Gene: 17126 Mouse Entrez Gene: 17127 Mouse Entrez Gene: 25631 Rat Entrez Gene: 29357 Rat Omim: 601366 Human Omim: 603109 Human SwissProt: P84022 Human SwissProt: Q15796 Human SwissProt: Q62432 Mouse SwissProt: Q8BUN5 Mouse SwissProt: O70436 Rat SwissProt: P84025 Rat Unigene: 12253 Human Unigene: 714621 Human Unigene: 10636 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化细胞信号转导分子SMAD2/SMAD3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞凋亡 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid