RNA结合蛋白NOB1抗体
规格：1mg/1ml
英文名： NOB1
别名： Adenocarcinoma antigen recognized by T lymphocytes 4; ART4; MST158; MSTP158; Nin one binding protein; NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); nob1; NOB1_HUMAN; NOB1P; Phosphorylation reg
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NOB1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞核
RNA结合蛋白NOB1抗体产品介绍：background: NOB1P is a 412 amino acid nuclear protein that is involved in proteosome biogenesis and is required for the final step in 18S rRNA maturation. NOB1P contains a PIN domain, which functions as a nuclease in nonsense-mediated mRNA decay and is required for pre-rRNA cleavage. NOB1P interacts with Rent2, which is involved in nonsense-mediated decay of mRNAs containing premature stop codons. Expressed in placenta, spleen, endothelial cells, liver and lung, NOB1P is essential for the synthesis of 40S ribosome subunits. Supression of the gene encoding NOB1P inhibits the processing of the 20S pre-rRNA to the mature 18S rRNA, thereforeRNA结合蛋白NOB1抗体 leading to accumulation of high levels of 20S pre-rRNA with degradation intermediates. Function: May play a role in mRNA degradation. Subcellular Location: Nucleus. Tissue Specificity: Detected in liver, lung, placenta, endothelial cells and spleen. Similarity: Belongs to the NOB1 family. Contains 1 PINc domain. Gene ID: 28987 Database links: Entrez Gene: 28987 Human Entrez Gene: 67619 Mouse Entrez Gene: RNA结合蛋白NOB1抗体291996 Rat Omim: 613586 Human SwissProt: Q9ULX3 Human SwissProt: Q8BW10 Mouse SwissProt: Q6VEU1 Rat Unigene: 271695 Human Unigene: 334793 Mouse Unigene: 102586 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RNA结合蛋白NOB1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 染色质和核信号 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid