去泛素化酶15抗体

去泛素化酶15抗体

规格：1mg/1ml

英文名： USP15

别名： Deubiquitinating enzyme 15; Deubiquitinating enzyme; EC 3 1 2 15; KIAA0529; MGC131982; MGC149838; MGC74854; Ubiquitin Carboxy terminal Hydrolase 15; Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin

分子量： 112kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human USP15

交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,

细胞定位：细胞核 细胞浆

去泛素化酶15抗体产品介绍：Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16去泛素化酶15抗体protein E6 against degradation via the ubiquitin proteasome pathway. Subunit: A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. Interacts with human papillomavirus type 16 protein E6 Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues. Post-translational modifications: Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome. 去泛素化酶15抗体Ubiquitinated, leading to degradation by the proteasome. Similarity: Belongs to the peptidase C19 family. Contains 1 DUSP domain. Gene ID: 9958 Database links: Entrez Gene: 395644 Chicken Entrez Gene: 538284 Cow Entrez Gene: 100055857 Horse Entrez Gene: 9958 Human Entrez Gene: 14479 Mouse Entrez Gene: 100356438 Rabbit Entrez Gene: 171329 Rat Entrez Gene: 100542201 Turkey Omim: 604731 Human SwissProt: Q9Y4E8 Human SwissProt: Q8R5H1 Mouse Unigene: 434951 Human Unigene: 244209 Mouse Unigene: 470032 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

去泛素化酶15抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  信号转导  表观遗传学  泛素  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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