磷酸肌醇相互作用蛋白2抗体
规格：1mg/1ml
英文名： WIPI2/Atg21
别名： ATG18B; Atg21; CGI 50; DKFZp434J154; DKFZp686P02188; FLJ12979; FLJ14217; FLJ42984; WD repeat domain phosphoinositide-interacting protein 2; WD repeat domain, phosphoinositide interacting 2; WD40 repea
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human WIPI2/At
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞浆
磷酸肌醇相互作用蛋白2抗体产品介绍：background: WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008] Function: Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. Subunit: Interacts with TECPR1. Subcellular Location: Preautophagosomal structure 磷酸肌醇相互作用蛋白2抗体membrane. Enriched at preautophagosomal structure membranes in response to ptdIns3P. Tissue Specificity: Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. Similarity: Belongs to the WD repeat SVP1 family. Contains 3 WD repeats. Gene ID: 26100 Database links: Entrez Gene: 26100 Human磷酸肌醇相互作用蛋白2抗体 Entrez Gene: 74781 Mouse Entrez Gene: 288498 Rat Omim: 609225 Human SwissProt: Q9Y4P8 Human SwissProt: Q80W47 Mouse SwissProt: Q6AY57 Rat Unigene: 122363 Human Unigene: 29432 Mouse Unigene: 163194 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸肌醇相互作用蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 细胞自噬
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid