类固醇生成因子1核受体抗体
规格：1mg/1ml
英文名： Steroidogenic Factor 1/NR5A1
别名： AD4BP; Adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ 1; FTZ1; FTZF 1; FTZF1; Fushi tarazu factor (Drosophila) homolog 1; Fushi tarazu factor homolog 1; NR5A1; Nuclear receptor AdBP4;
分子量： 52kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Steroido
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
类固醇生成因子1核受体抗体产品介绍：background: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Subcellular Location: Nucleus. Post-translational modifications: Acetylation stimulates the transcriptional activity. DISEASE: Defects in NR5A1 are a cause of 46,XY disorder of sex development (46,XY DSD) [MIM:612965];类固醇生成因子1核受体抗体 also known as XY sex reversal with or without adrenal failure. A congenital condition in which development of chromosomal, gonadal, or antomic sex is atypical. 46,XY DSD is a disorder of gonadal (testicular) development, which may be complete or partial. The complete form includes streak gonads, normal mullerian structures, and normal female external genitalia. The partial form includes ambiguous external genitalia and partial development of mullerian and wolffian structures. Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect (ACIWOD) [MIM:184757]. ACIWOD is characterized by severe 'slackness' muscular hypotonia. There is decreased sodium, increased potassium and elevated类固醇生成因子1核受体抗体 ACTH. Defects in NR5A1 are the cause of premature ovarian failure type 7 (POF7) [MIM:612964]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Similarity: Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 2516 Database links: Entrez Gene: 281948 Cow Entrez Gene: 100033902 Horse Entrez Gene: 2516 Human Entrez Gene: 26423 Mouse Entrez Gene: 397368 Pig Entrez Gene: 83826 Rat Omim: 184757 Human SwissProt: Q04752 Cow SwissProt: Q9GKL2 Horse SwissProt: Q13285 Human SwissProt: P33242 Mouse SwissProt: P79387 Pig SwissProt: P50569 Rat Unigene: 495108 Human Unigene: 31387 Mouse Unigene: 6586 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
类固醇生成因子1核受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 染色质和核信号 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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