G蛋白家族RAB13蛋白抗体
规格：1mg/1ml
英文名： RAB13
别名： Cell growth-inhibiting gene 4 protein; GIG4; Growth inhibiting gene 4 protein; RAB13; RAB13 member RAS oncogene family; RAB13_HUMAN; RAS associated protein RAB13; Ras related protein Rab13; Ras-relate
分子量： 23kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RAB13
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
G蛋白家族RAB13蛋白抗体细胞定位：细胞浆 细胞膜
产品介绍：background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membraneG蛋白家族RAB13蛋白抗体 of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. Subunit: Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with CCDC64B/BICDR2. Interacts with LEPROT and LEPROTL1. Subcellular Location: Cell junction > tight junction. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Tissue Specificity: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells. Similarity: Belongs to the small GTPase superfamily. Rab family. Gene ID: 5872 G蛋白家族RAB13蛋白抗体Database links: Entrez Gene: 514541 Cow Entrez Gene: 5872 Human Entrez Gene: 68328 Mouse Entrez Gene: 81756 Rat Entrez Gene: 373105 Zebrafish Omim: 602672 Human SwissProt: Q58DS5 Cow SwissProt: P51153 Human SwissProt: Q5U0A6 Human SwissProt: Q9DD03 Mouse SwissProt: P35286 Rat SwissProt: Q7T3A4 Zebrafish Unigene: 151536 Human Unigene: 29355 Mouse Unigene: 9819 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白家族RAB13蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid