SHC4蛋白抗体
规格：1mg/1ml
英文名： SHC4
别名： hShcD; MGC34023; Rai like protein; Rai-like protein; RaLP; SH2 domain protein C4; SHC (Src homology 2 domain containing) family member 4; SHC 4; SHC; SHC family member 4; SHC transforming protein 4; S
分子量： 69kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SHC4
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：
SHC4蛋白抗体产品介绍：Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. Subunit: Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-424 phosphorylation and increased by EGF. Subcellular Location: Cell junction > synapse > postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction. Tissue Specificity: Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. HighlySHC4蛋白抗体 expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. Post-translational modifications: Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2. Similarity: Contains 1 PID domain. Contains 1 SH2 domain. Gene ID: 399694 SHC4蛋白抗体Database links: Entrez Gene: 399694 Human SwissProt: Q6S5L8 Human Unigene: 642615 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SHC4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid