细胞外基质磷酸化抗体
规格：1mg/1ml
英文名： MEPE
别名： Matrix extracellular phosphoglycoprotein; MEPE; MEPE_HUMAN; OF45; Osteoblast/osteocyte factor 45.
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MEPE
交叉反应：Human,
细胞定位：分泌型蛋白
细胞外基质磷酸化抗体产品介绍：background: MEPE is a 525 amino acid extracellular matrix protein. Expressed in osteocytes and brain, MEPE is a regulator of bone metabolism that is thought to mediate mineralization and demineralization within the osteocyte microenvironment. MEPE contains an RGD cell-attachment motif and shares molecular similarities with several dentin-bone extracellular matrix RGD-containing phosphoglycoproteins, including OPN (osteopontin) and DSP (dentin sialophosphoprotein). Via its ability to control bone mineralization, MEPE is associated with various developmental events such as skeletogenesis, bone regeneration and odontogenesis. MEPE is secreted in 细胞外基质磷酸化抗体hypophosphatemic osteomalacia tumors, suggesting a possible role in the pathophysiology of bone-related cancers. Function: Seems to play a role in mineralization. Subcellular Location: Secreted Tissue Specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors. Post-translational modifications: Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the细胞外基质磷酸化抗体 S-x-E/pS motif. Gene ID: 56955 Database links: Entrez Gene: 56955 Human Entrez Gene: 94111 Mouse Entrez Gene: 79110 Rat Omim: 605912 Human SwissProt: Q9NQ76 Human Unigene: 676357 Human Unigene: 196672 Mouse Unigene: 160717 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞外基质磷酸化抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 发育生物学 信号转导 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid