G0/G1期开关调节蛋白2抗体
规格：1mg/1ml
英文名： G1switch 2
别名： G0/G1 switch regulatory protein 2; G0/G1switch 2; G0s2; G0S2_HUMAN; OTTHUMP; Putative lymphocyte G0/G1 switch protein 2; RP1 28O10.2.
分子量： 11kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human G0/G1 sw
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞浆
G0/G1期开关调节蛋白2抗体产品介绍：background: G0S2 is a 103 amino acid novel target of peroxisome proliferator-activated receptors (PPARs) and regulator of latent HIV. G0S2 may be involved in adipocyte differentiation and its expression is essential for committing cells to enter the G1 phase of the cell cycle. G0S2 contains a CpG-rich island and multiple sites for potential phosphorylation by casein kinase II and protein kinase C. The gene encoding G0S2 maps to human chromosome 1, which is the largest human chromosome. Chromosome 1 spans about 260 million base pairs and makes up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford G0/G1期开关调节蛋白2抗体progeria is associated with the LMNA gene which encodes lamin A. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. Function: Potential oncogene and regulator of latent HIV. Subunit: Directly interacts with BCL2; G0/G1期开关调节蛋白2抗体this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex. Subcellular Location: Mitochondrion. Tissue Specificity: Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver. Database links: UniProtKB/Swiss-Prot: P27469. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G0/G1期开关调节蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid