DNA修复甲基磺酸敏感性基因19抗体
规格：1mg/1ml
英文名： MMS19
别名： MET18MMS19 nucleotide excision repair homolog; methyl methanesulfonate sensitivity gene19; MMS19L; MMS-19L; MMS 19 nucleotide excision repair homolog MET18.
分子量： 113kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MMS 19
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
细胞定位：细胞核
DNA修复甲基磺酸敏感性基因19抗体产品介绍：background: MMS19 is a 1,030 amino acid nuclear protein containing seven HEAT repeats that belongs to the MET18/MMS19 family. Via its interactions with TFIIH p80 and TFIIH p89 helicases, MMS19 plays a role in nucleotide excision repair (NER) and RNA polymerase II (Pol II) transcription. MMS19 may also function as a transcriptional coactivator of estrogen receptor. While ubiquitously expressed, highest levels of MMS19 have been found in testis. At least five distinct MMS19 protein isoforms exist, which are produced by alternative splicing events. The gene encoding MMS19 maps to human chromosome 10q24.1, and is associated with the risk of pancreatic cancer. Function: MMS19 like protein may play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. It may also function as a transcriptional coactivatorDNA修复甲基磺酸敏感性基因19抗体 of estrogen receptor (ER) and may be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types. It is ubiquitously expressed with higher expression in testis. Subunit: Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interactionDNA修复甲基磺酸敏感性基因19抗体 is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Subcellular Location: Nuclear. Tissue Specificity: Ubiquitously expressed with higher expression in testis. Similarity: Belongs to the MET18/MMS19 family. Contains 7 HEAT repeats. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNA修复甲基磺酸敏感性基因19抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 染色质和核信号 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid