核蛋白相互作用蛋白2抗体
规格：1mg/1ml
英文名： KPNA2
别名： IMA2_HUMAN; Importin alpha 1; Importin alpha 2; Importin alpha 2 subunit; Importin alpha P1; Importin subunit alpha-2; IPO A1; IPOA 1; IPOA1; Karyopherin alpha 2; Karyopherin alpha 2 RAG cohort 1; Kar
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KPNA2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
核蛋白相互作用蛋白2抗体产品介绍：background: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008] Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1核蛋白相互作用蛋白2抗体 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed ubiquitously. Similarity: Belongs to the importin alpha family. Contains 10 ARM repeats. Contains核蛋白相互作用蛋白2抗体 1 IBB domain. Gene ID: 3838 Database links: Entrez Gene: 3838 Human Entrez Gene: 100039592 Mouse Entrez Gene: 100043906 Mouse Entrez Gene: 16647 Mouse Omim: 600685 Human SwissProt: P52292 Human SwissProt: P52293 Mouse Unigene: 594238 Human Unigene: 12508 Mouse Unigene: 391577 Mouse Unigene: 423000 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核蛋白相互作用蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid