磷酸化胞浆型磷脂酶A2抗体
规格：1mg/1ml
英文名： phospho-CPLA2 (Ser505)
别名： CPLA2(phospho-Ser505); CPLA2(phospho-S505); p-CPLA2 (Ser505); p-CPLA2 (S505); Calcium dependent phospholipid binding protein; CPLA 2; cPLA2 alpha; cPLA2; Cytosolic phospholipase A2; Cytosolic phosphol
分子量： 82kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
磷酸化胞浆型磷脂酶A2抗体产品介绍：background: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]. Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing磷酸化胞浆型磷脂酶A2抗体 arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Subunit: Interacts with KAT5. Subcellular Location: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Tissue Specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. Post-translational modifications: Activated by phosphorylation at both Ser-505 and Ser-727. Similarity: Contains 1 C2 domain. Contains 1 PLA2c domain磷酸化胞浆型磷脂酶A2抗体. Database links: UniProtKB/Swiss-Prot: P47712.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化胞浆型磷脂酶A2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid