少突胶质细胞转录因子1
规格：1mg/1ml
英文名： OLIG1
别名： Oligo 1; Oligo1; Oligodendrocyte lineage transcription factor 1; Oligodendrocyte specific bHLH transcription factor 1; Oligodendrocyte transcription factor 1. Basic domain helix loop helix protein cla
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OLIG1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞核
少突胶质细胞转录因子1产品介绍：background: The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain. Function: romotes formation and maturation of oligodendrocytes, especially within the brain.少突胶质细胞转录因子1 Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Database links: Entrez Gene: 116448 Human Entrez Gene: 50914 Mouse Entrez Gene: 60394 Rat Omim: 606385 Human SwissProt: Q8TAK6 Human SwissProt: Q9JKN5 Mouse SwissProt:少突胶质细胞转录因子1 Q9WUQ3 Rat Unigene: 56663 Human Unigene: 39300 Mouse Unigene: 45339 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产少突胶质细胞转录因子1品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid