肌动蛋白结合蛋白CORO1A抗体
规格：1mg/1ml
英文名： Coronin 1a
别名： actin binding protein; CLABP; Clipin A; Clipin-A; CLIPINA; COR1A_HUMAN; CORO1A; coronin 1; Coronin actin binding protein 1A; Coronin like protein A; Coronin like protein p57; coronin, actin binding pr
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Coronin
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
肌动蛋白结合蛋白CORO1A抗体产品介绍：background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010] Function: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Subunit: Binds actin. Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane.肌动蛋白结合蛋白CORO1A抗体 Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification. Tissue Specificity: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut. Similarity: Belongs to the WD repeat coronin family. Contains 7 WD repeats. Gene ID: 11151 Database links: Entrez Gene: 肌动蛋白结合蛋白CORO1A抗体11151 Human Entrez Gene: 12721 Mouse Entrez Gene: 155151 Rat Omim: 605000 Human SwissProt: P31146 Human SwissProt: O89053 Mouse SwissProt: Q91ZN1 Rat Unigene: 415067 Human Unigene: 290482 Mouse Unigene: 6990 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌动蛋白结合蛋白CORO1A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导 结合蛋白 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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