内质网膜蛋白UNC93B抗体
规格：1mg/1ml
英文名： UNC93B
别名： hUNC93B1; Protein unc 93 homolog B1; Protein UNC 93B; unc 93 homolog B1; unc 93 homolog B1 (C elegans); unc 93 related protein; unc93 (C elegans) homolog B; unc93 (C elegans) homolog B1; UNC93; UNC93B
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UNC93B
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
内质网膜蛋白UNC93B抗体产品介绍：background: UNC93B is a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. Defects in UNC93B are associated with susceptibility to herpes simplex encephalitis (HSE) which is a rare complication of human herpesvirus 1 (HHV-1) infection. Function: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. Subunit: Interacts with TLR3, TLR7, and TLR9 (probably via transmembrane domain). Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. Post-translational modifications: N-glycosylated (By similarity). DISEASE: Defects in UNC93B1 are associated with herpes simplex encephalitis type 1 (HSE1) [MIM:610551].内质网膜蛋白UNC93B抗体 HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=Mutations in UNC93B1 resulting in autosomal recessive UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to impaired IFNs production. UNC93B1 deficieny,内质网膜蛋白UNC93B抗体 however, does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Similarity: Belongs to the unc-93 family. Database links: UniProtKB/Swiss-Prot: Q9H1C4.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内质网膜蛋白UNC93B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid