膜内在蛋白NOD26抗体
规格：1mg/1ml
英文名： NOD26/NLRX1
别名： Caterpiller protein 11.3; CLR11.3; DLNB26; NLR family member X1 NLR family, X1 Nlrx1 NLRX1_HUMAN NOD-like receptor X1 NOD26 NOD5 NOD9 Nucleotide-binding oligomerization domain protein 26 Nucleotide-bi
分子量： 98kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NLRX1/NO
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
膜内在蛋白NOD26抗体产品介绍：background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. NOD9, also known as NLRX1, NOD26 or NOD5, is a 975 amino acid outer mitochondrial membrane protein that contains one NACHT domain and four LRR repeats. Expressed at high levels in heart, muscle and mammary gland, NOD9 plays a role in antiviral signaling, specifically via inhibition of virus-induced helicases, thereby acting as a negative regulator of antiviral responses. Two isoforms of NOD9 exist due to alternative splicing events. Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances膜内在蛋白NOD26抗体NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Subunit: Interacts with MAVS. Subcellular Location: Mitochondrion outer membrane. Tissue Specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level). Similarity: Belongs to the NLRP family. Contains 7 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Database links: Entrez Gene: 539974 Cow Entrez Gene: 489370 Dog 膜内在蛋白NOD26抗体Entrez Gene: 100071383 Horse Entrez Gene: 79671 Human Entrez Gene: 270151 Mouse Entrez Gene: 315599 Rat Omim: 611947 Human SwissProt: Q86UT6 Human SwissProt: Q3TL44 Mouse SwissProt: Q5FVQ8 Rat Unigene: 524082 Human Unigene: 3957 Mouse Unigene: 12444 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
膜内在蛋白NOD26抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid