Ⅲ型纤维连接蛋白域蛋白2/5抗体
规格：1mg/1ml
英文名： FNDC5
别名： FNDC5; Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; F
分子量： 12/20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FNDC5 Ir
交叉反应：Human, Mouse, Rat, Chicken, Dog, Rabbit,
细胞定位：细胞浆 细胞膜 分泌型蛋白
Ⅲ型纤维连接蛋白域蛋白2/5抗体产品介绍：background: This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. Function: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity). Subcellular Location: Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein (By similarity). Note=Imported in peroxisomes through theⅢ型纤维连接蛋白域蛋白2/5抗体 PEX5 receptor pathway (By similarity). Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. Post-translational modifications: The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. Similarity: Contains 1 fibronectin type-III domain. Gene ID: 252995 Database links: Entrez Gene: 252995 Human Entrez Gene: 384061 Mouse EntrezⅢ型纤维连接蛋白域蛋白2/5抗体 Gene: 260327 Rat Omim: 611906 Human SwissProt: Q8NAU1 Human SwissProt: Q8K4Z2 Mouse SwissProt: Q8K3V5 Rat Unigene: 524234 Human Unigene: 44075 Mouse Unigene: 18757 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Ⅲ型纤维连接蛋白域蛋白2/5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid