Ⅲ型纤维连接蛋白域蛋白1抗体
规格：1mg/1ml
英文名： FNDC1
别名： Activation-associated cDNA protein; AGS8; Expressed in synovial lining protein; fibronectin type III domain containing 2; Fibronectin type III domain-containing protein 1; FNDC1; FNDC1_HUMAN; FNDC2; M
分子量： 202kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FNDC1
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
Ⅲ型纤维连接蛋白域蛋白1抗体细胞定位：分泌型蛋白
产品介绍：background: FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G∫ and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy Ⅲ型纤维连接蛋白域蛋白1抗体skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events. Function: May be an activator of G protein signaling Subcellular Location: Secreted. Tissue Specificity: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis. Similarity:Ⅲ型纤维连接蛋白域蛋白1抗体 Contains 5 fibronectin type-III domains. Database links: UniProtKB/Swiss-Prot: Q4ZHG4.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Ⅲ型纤维连接蛋白域蛋白1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid