蛋白激酶MST1/2抗体
规格：1mg/1ml
英文名： MST1/MST2
别名： DKFZp686A2068; FLJ90748; KRS1; KRS2; Mammalian STE20 like protein kinase 1; Mammalian STE20 like protein kinase 2; MST 1; MST 2; MST1; MST2; Serine/threonine kinase 3 (STE20 homolog yeast); Serine/thr
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MST1/MST
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig, Cat, Chimpanzee, Rhesus monkey, Gorilla, Tilapia, Orangutan, Xenopus tropical
细胞定位：细胞核 细胞浆
蛋白激酶MST1/2抗体产品介绍：background: This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Function: The human serine/threonine kinase, mammalian STE20 like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor mediated apoptosis by accelerating caspase 3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation. MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. Mammalian Sterile 20 Like 2 (MST2) is most similar to the previously蛋白激酶MST1/2抗体 identified MST1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in ***** kidney, skeletal and placental tissues and at very low levels in ***** heart, lung, liver and brain tissues. An in vitro kinase assay indicates that MST2 can phosphorylate an exogenous substrate, as well as itself, and phospho amino acid analysis indicates that it is a serine/threonine protein kinase. Subcellular Location: Cytoplasm. Nucleus. Note: The caspase cleaved form cycles between the nucleus and cytoplasm. Gene ID: 6788 6789 Database蛋白激酶MST1/2抗体 links: Entrez Gene: 6788 Human Entrez Gene: 6789 Human Entrez Gene: 311622 Rat Entrez Gene: 65189 Rat Omim: 604965 Human Omim: 605030 Human SwissProt: Q13043 Human SwissProt: Q13188 Human SwissProt: O54748 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产蛋白激酶MST1/2抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 细胞凋亡 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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