氨基己糖苷酶D抗体
规格：1mg/1ml
英文名： HEXDC
别名： Beta hexosaminidase D; Beta N acetylhexosaminidase; FLJ23825; Hexosaminidase (glycosyl hydrolase family 20 catalytic domain) containing; hexosaminidase (glycosyl hydrolase family 20, catalytic domain;
分子量： 54 kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HEXDC
交叉反应：Human, Mouse, Rat, Dog, Horse,
氨基己糖苷酶D抗体细胞定位：细胞核 细胞浆
产品介绍：background: HEXDC, also known as hexosaminidase D, beta-hexosaminidase D, N-acetyl-beta-galactosaminidase, hexosaminidase domain-containing protein or beta-N-acetylhexosaminidase, is a 486 amino acid cytoplasmic and nuclear protein that has hexosaminidase activity and belongs to the glycosyl hydrolase 20 family. Existing as two alternatively spliced isoforms, HEXDC catalyzes the hydrolysis of non-reducing N-acetyl-D-hexosamine residues near the termini of N-acetyl-beta-D-hexosaminides. The gene encoding HEXDC maps 氨基己糖苷酶D抗体to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Defects in p53 is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is directly involved in DNA repair and is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Has hexosaminidase activity. Subunit: Homodimer; 氨基己糖苷酶D抗体disulfide-linked (By similarity). Subcellular Location: Cytoplasmic and Nuclear Similarity: Belongs to the glycosyl hydrolase 20 family. Database links: UniProtKB/Swiss-Prot: Q8WVB3.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氨基己糖苷酶D抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid