泛素蛋白连接酶E1抗体
规格：1mg/1ml
英文名： UBE2E1
别名： UB2E1_HUMAN; UbcH6; UBE2E1; Ubiquitin carrier protein E1; Ubiquitin-conjugating enzyme E2 E1; Ubiquitin-protein ligase E1.
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UBCH6/UB
交叉反应：Mouse, Rat, Chicken, Pig, Cow, Sheep,
细胞定位：细胞核
泛素蛋白连接酶E1抗体产品介绍：background: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2E1 and UBE2L3, also designated UBCH6 and UBCH7 respectively in human, are E2 conjugating enzymes that interact with various proteins. Specifically, UBE2E1 interacts with the tumor suppressor protein TSSC5. UBE2L3 has been shown to mediate c-fos degradation, NF-kB maturation, human papilloma virus-mediated p53 and Myc protein degradation. Function: Accepts ubiquitin from the E1 complex and泛素蛋白连接酶E1抗体catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Subunit: Interacts with RNF14. Subcellular Location: Nucleus. Post-translational modifications: ISGylation suppresses ubiquitin E2 enzyme activity. Similarity泛素蛋白连接酶E1抗体: Belongs to the ubiquitin-conjugating enzyme family. Gene ID: 7324 Database links: Entrez Gene: 7324 Human Entrez Gene: 22194 Mouse Omim: 602916 Human SwissProt: P51965 Human SwissProt: P52482 Mouse SwissProt: Q541Z5 Mouse Unigene: 164853 Human Unigene: 4429 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
泛素蛋白连接酶E1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid