泛素结合酶E2 230K抗体
规格：1mg/1ml
英文名： UBE2O
别名： E2 230K; ubiquitin-conjugating enzyme E2O; EC=6.3.2.19; FLJ12878; KIAA1734; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme; RP23 193A16.5; UBE2O; UBE2O_HUMAN; Ubiquitin carrier protein O; Ubiqu
分子量： 141kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UBE2O/E2
交叉反应：Mouse, Rat, Chicken, Pig, Horse,
细胞定位：
泛素结合酶E2 230K抗体产品介绍：background: UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is 泛素结合酶E2 230K抗体associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Tissue Specificity: Predominantly 泛素结合酶E2 230K抗体expressed in skeletal muscle and heart. Similarity: Belongs to the ubiquitin-conjugating enzyme family. Gene ID: 63893 Database links: Entrez Gene: 63893 Human Entrez Gene: 217342 Mouse SwissProt: Q9C0C9 Human SwissProt: Q6ZPJ3 Mouse Unigene: 16130 Human Unigene: 243950 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
泛素结合酶E2 230K抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid