NOGO相互作用线粒体蛋白1抗体
规格：1mg/1ml
英文名： NIMP/RTN4IP1
别名： mitochondrial; NIMP; NOGO interacting mitochondrial protein; NOGO-interacting mitochondrial protein; Reticulon 4 interacting protein 1; Reticulon 4 interacting protein 1, mitochondrial; Reticulon-4-in
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NIMP/RTN
交叉反应：Human, Mouse, Rat, Pig, Rabbit,
细胞定位：细胞浆 线粒体
NOGO相互作用线粒体蛋白1抗体产品介绍：background: Appears to be a potent inhibitor of regeneration following spinal cord injury.Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NIMP (NOGO-interacting mitochondrial protein), also known as RTN4IP1 (Reticulon-4-interacting protein 1), is a 396 amino NOGO相互作用线粒体蛋白1抗体acid mitochondrial protein that contains a C-terminal oxidoreductaselike domain and numerous sites for phosphorylation. NIMP is expressed in mitochondrial-rich tissue such as kidney, heart, skeletal muscle and specific regions within the nervous system. Through interaction with Nogo, it is likely that NIMP plays a role in Nogo-induced inhibition of neurite growth. There are three isoforms of NIMP that are produced as a result of alternative splicing events. Function: Appears to be a potent inhibitor of regeneration following spinal cord injury. Subunit: Interacts with RTN4, UQCRC1 and UQCRC2 (By similarity). Subcellular Location: Mitochondrion. Tissue Specificity: Widely expressed in mitochondria-enriched tissues.NOGO相互作用线粒体蛋白1抗体 Found in heart, muscle, kidney, liver, brain and placenta. Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Database links: Entrez Gene: 506626 Cow Entrez Gene: 84816 Human Entrez Gene: 170728 Mouse Entrez Gene: 309912 Rat Omim: 610502 Human SwissProt: Q0VC50 Cow SwissProt: Q8WWV3 Human SwissProt: Q924D0 Mouse Unigene: 155839 Human Unigene: 390253 Mouse Unigene: 220185 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NOGO相互作用线粒体蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid