二肽基肽酶9抗体
规格：1mg/1ml
英文名： DPP9
别名： Dipeptidyl peptidase IV related protein 2; Dipeptidyl peptidase 9; Dipeptidyl peptidase IV related protein 2; Dipeptidyl peptidase IV-related protein 2; Dipeptidyl peptidase IX; Dipeptidyl peptidase l
分子量： 98kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DPP9/DPR
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：细胞浆
二肽基肽酶9抗体产品介绍：background: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPRP2 (dipeptidyl-peptidase IV-related protein 2), also known as DPP9 (dipeptidyl-peptidase 9), or DP9, is a member of the peptidase S9B family of proteins that exhibit prolyl oligopeptidase activity. DPRP2 localizes to the cytoplasm and is ubiquitously expressed with predominant expression in heart, muscle and liver. DPRP2 may play an important role in the regulation of signaling by peptide hormones. Function: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of二肽基肽酶9抗体 steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). Subcellular Location: Cytoplasm, cytosol. Tissue Specificity: Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain. Similarity: Belongs to the peptidase S9B family. DPPIV subfamily. Database links: UniProtKB/Swiss-Prot: Q86TI2.3 Entrez Gene: 91039 Human Entrez Gene: 224897 二肽基肽酶9抗体Mouse Entrez Gene: 301130 Rat Omim: 608258 Human SwissProt: Q86TI2 Human SwissProt: Q8BVG4 Mouse Unigene: 515081 Human Unigene: 205535 Mouse Unigene: 41201 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
二肽基肽酶9抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 发育生物学 信号转导 糖尿病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid