含亮氨酸神经胶质瘤失活蛋白4抗体
规格：1mg/1ml
英文名： LGI4
别名： Leucine rich glioma inactivated gene 4; Leucine rich glioma inactivated protein 4; leucine-rich repeat LGI family member 4; Leucine rich repeat LGI family member 4; LGI1 like protein 3; LGI4; Lgi4 pro
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LGI4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：分泌型蛋白
含亮氨酸神经胶质瘤失活蛋白4抗体产品介绍：background: LGI4, also known as leucine-rich glioma-inactivated protein 4, is a 537 amino acid secreted glycosylated protein that is widely expressed, with highest levels found within the nervous system. Interestingly, siRNA knockdown studies of LGI4 expression in Schwann cells have been shown to result in the inhibition of myelination, thus suggesting that LGI4 is an essential component of myelin formation and axon segregation. LGI4 shares significant homology with its other family members, LGI1, LGI2 and LGI3. Significantly, mutations in the gene encoding LGI1 have been linked to human temporal lobe epilepsy and, given the sequence 含亮氨酸神经胶质瘤失活蛋白4抗体similarity of LGI4, it is likely that it also may be implicated in the pathology of seizures. LGI4 is localized subcellularly to the Golgi, ER and vesicles. There are two isoforms of LGI4 that are produced as a result of alternative splicing events. Subunit: Can bind to ADAM11, ADAM22 and ADAM23 (By similarity). Subcellular Location: Secreted Tissue Specificity: Widely expressed, with highest expression in brain含亮氨酸神经胶质瘤失活蛋白4抗体. Similarity: Contains 4 EAR repeats. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Database links: UniProtKB/Swiss-Prot: Q8N135.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
含亮氨酸神经胶质瘤失活蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 干细胞 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid