GTP酶IMAP家族成员5抗体
规格：1mg/1ml
英文名： GIMAP5
别名： HIMAP3; IAN4; IAN4L1; IAN5; IMAP3; FLJ11296; GIMAP 5; GTPase IMAP family member 5; GTPase, IMAP family member 5; immunity-associated nucleotide 5; hIAN5; IAN 5; Immune associated nucleotide 4 like 1;
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from huam GIMAP5
交叉反应：Human,
细胞定位：细胞浆 细胞膜
GTP酶IMAP家族成员5抗体产品介绍：background: GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus. Function: Required for mitochondrial integrity and T-cell survival. May GTP酶IMAP家族成员5抗体contribute to T-cell quiescence (By similarity). Subcellular Location: Mitochondrion outer membrane; Single-pass type IV membrane protein (By similarity). Lysosome. Tissue Specificity: Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasmsGTP酶IMAP家族成员5抗体. Similarity: Belongs to the IAN GTP-binding protein family. Database links: UniProtKB/Swiss-Prot: Q96F15.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产GTP酶IMAP家族成员5抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 t-**细胞 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid