干扰肾细胞癌蛋白2抗体
规格：1mg/1ml
英文名： DIRC2
别名： Disrupted in renal carcinoma protein 2; DIRC 2; Disrupted in renal cancer protein 2; Disrupted in renal carcinoma 2; FLJ14784; NP_116228; RCC 4; RCC4; Renal cell carcinoma 4; DIRC2_HUMAN.
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DIRC2
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
干扰肾细胞癌蛋白2抗体产品介绍：background: Belonging to the major facilitator superfamily, DIRC2 (disrupted in renal carcinoma protein 2) is a 478 amino acid multi-pass membrane protein that is primarily expressed in kidney proximal tubular cells. The genes encoding DIRC2 and DIRC3 are located at a translocation breakpoint which occurs frequently in individuals affected by familial renal cell carcinoma. Fusion transcripts that result from these translocations may affect normal protein function. This evidence suggests that, due to its chromosomal location, deregulation of the DIRC2 gene may cause haploinsufficiency and therefore result in the onset of tumor growth. There are two 干扰肾细胞癌蛋白2抗体isoforms of DIRC2 which are produced as a result of alternative splicing events. Function: Electrogenic metabolite transporter. Subcellular Location: Lysosome membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitous. Expressed in proximal tubular cells of the kidney. Post-translational modifications: Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated干扰肾细胞癌蛋白2抗体 N-terminal and a non-glycosylated C-terminal fragment. DISEASE: Note=A chromosomal aberration involving DIRC2 has been found in a family with renal carcinoma. Translocation t(2;3)(q35;q21). Similarity: Belongs to the major facilitator superfamily. Database links: UniProtKB/Swiss-Prot: Q96SL1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰肾细胞癌蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid