二氢嘧啶抗体
规格：1mg/1ml
英文名： Dihydropyrimidinase
别名： DHP; DHPase; Dihydropyrimidinase; Dihydropyrimidine amidohydrolase; Dpys; DPYS_HUMAN; Hydantoinase.
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DHP/Dihy
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
细胞定位：
二氢嘧啶抗体产品介绍：background: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyzes the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Tissue specificity:Liver and kidney. Involvement in disease: Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy.二氢嘧啶抗体 Function: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Subcellular Location: Homotetramer (Probable). Tissue Specificity: Liver and kidney. Post-translational modifications: Carbamylation allows a single lysine to coordinate two zinc ions (By similarity). DISEASE: Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD) [MIM:222748]. DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, 二氢嘧啶抗体dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Database links: UniProtKB/Swiss-Prot: Q14117.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
二氢嘧啶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid