细胞分裂周期样激酶3抗体
规格：1mg/1ml
英文名： CLK3
别名： CDC like kinase 3; CDC-like kinase 3; CLK3; CLK3_HUMAN; Dual specificity protein kinase CLK3.
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from huamn CLK3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞核 细胞浆
产细胞分裂周期样激酶3抗体品介绍：background: Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Subcellular Location: Isoform 1: Nucleus细胞分裂周期样激酶3抗体. Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. Tissue Specificity: Endothelial cells. Post-translational modifications: Autophosphorylates on all three types of residues (By similarity). Similarity: Belongs to the protein kinase superfamily. 细胞分裂周期样激酶3抗体CMGC Ser/Thr protein kinase family. Lammer subfamily. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: P49761.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞分裂周期样激酶3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid