泛素结合酶E2变异体1抗体
规格：1mg/1ml
英文名： UBE2V1
别名： CIR1; CROC-1; CROC1; CROC1A; TRAF6-regulated IKK activator 1 beta Uev1A; UB2V1_HUMAN; UBE2V 1; UBE2V; UBE2V1; Ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-
分子量： 16kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UBE2V1
交叉反应：Human, Mouse, Rat, Chicken, Pig, Horse, Sheep,
细胞定位：细胞核
泛素结合酶E2变异体1抗体产品介绍：background: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Function: Has no ubiquitin ligase activity on its own. TheUBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonicalpoly-ubiquitin chains that are linked through Lys-63. This type ofpoly-ubiquitination activates IKK and does not seem to involveprotein degradation by the proteasome. Plays a role in theactivation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.Mediates transcriptional activation of target genes. Plays a rolein the control of progress through the cell 泛素结合酶E2变异体1抗体cycle anddifferentiation. Plays a role in the error-free DNA repair pathwayand contributes to the survival of cells after DNA damage. Subunit: Heterodimer with UBE2N. Interacts (UBE2V2-UBE2Nheterodimer) with the E3 ligase STUB1 (via the U-box domain); thecomplex has a specific 'Lys-63'-linked polyubiquitination activity.Interacts with TRAF6. Subcellular Location: Nucleus. Note=Excluded from the nucleolus. Tissue Specificity: Highly expressed in thyroid, pancreas, spinalcord, lymph node, trachea, adrenal gland, bone marrow and pancreas.Detected a泛素结合酶E2变异体1抗体t low levels in heart, breast, placenta, brain, liver,kidney, stomach and lung. Similarity: Belongs to the ubiquitin-conjugating enzyme family. Database links: UniProtKB/Swiss-Prot: Q13404.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产泛素结合酶E2变异体1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导 细胞周期蛋白 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid