周期素L抗体
规格：1mg/1ml
英文名： Cyclin L
别名： Ania 6a; BM 001; CCNL 1; CCNL1; CCNL1_HUMAN; Cyclin L ania 6a; Cyclin L; Cyclin L gamma; Cyclin L1; Cyclin-L; Cyclin-L1.
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cyclin L
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep, Chimpanzee, mpanzee
细胞定位：细胞核
周期素L抗体产品介绍：background: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. Tissue specificity;Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). Function: Transcriptional regulator which participates inregulating the pre-mRNA splicing process. Seems to be involved inthe regulation of RNA polymerase II (pol II). Functions inassociation with cyclin-dependent kinases (CDKs) and has a role inthe second step of splicing. May be a candidate proto-oncogene inhead and neck squamous cell carcinomas (HNSCC). Inhibited by theCDK-specific inhibitor p21周期素L抗体 Subunit: Interacts with POLR2A via its hyperphosphorylatedC-terminal domain (CTD) (By similarity). Interacts with CDK11A,CDK11B, CDK12, CDK13 and SFRS2. Subcellular Location: Nucleus speckle (By similarity). Note=Morespecifically found in nuclear intrachromatin granules clusters(IGC), also called nuclear speckles, which are storage compartmentsfor nuclear proteins involved in mRNA processing (By similarity).周期素L抗体 Tissue Specificity: Ubiquitous with higher level in thymus.Overexpression in primary tumors of head and neck squamous cellcarcinomas (HNSCC). Similarity: Belongs to the cyclin family. Cyclin L subfamily. Database links: UniProtKB/Swiss-Prot: Q9UK58.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产周期素L抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid