细胞周期通道和神经细胞分化蛋白1抗体
规格：1mg/1ml
英文名： CEND1
别名： BM88; BM88 antigen; Cell cycle exit and neuronal differentiation 1; Cell cycle exit and neuronal differentiation protein 1; FLJ90066; MGC34326; CEND_HUMAN
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CEND1
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞膜
细胞周期通道和神经细胞分化蛋白1抗体产品介绍：background: BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions细胞周期通道和神经细胞分化蛋白1抗体. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A. Function: CEND1 is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. Subunit: Homodimer Subcellular Location:细胞周期通道和神经细胞分化蛋白1抗体 Membrane; Single-pass type IV membrane protein. Tissue Specificity: Neuron specific. Similarity: Belongs to the CEND1 family. Database links: UniProtKB/Swiss-Prot: Q8N111.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞周期通道和神经细胞分化蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞周期蛋白 细胞分化 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid