减数分裂内切酶EME1抗体
规格：1mg/1ml
英文名： EME1
别名： Crossover junction endonuclease EME1; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe); EME1, S. pombe, homolog of, 1; essential meiotic endonuclease 1 homolog 1 (S pombe); Essential Meiotic
分子量： 63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EME1
交叉反应：Human, Mouse, Rat, Dog, Rabbit, Sheep,
细胞定位：细胞核
产减数分裂内切酶EME1抗体品介绍：background: EME1 complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein (MUS81) to form an endonuclease complex which cleaves branched DNA structures, especially those arising during stalled DNA replication. The protein may be involved in repairing DNA damage and in maintaining genomic stability. It interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Alternative splicing results in multiple transcript variants. Function: Interacts with MUS81 to form a DNA structure-specificendonuclease with substrate preference for branched DNA structureswith a 5'-end减数分裂内切酶EME1抗体 at the branch nick. Typical substrates include3'-flap structures, replication forks and nicked Hollidayjunctions. May be required in mitosis for the processing of stalledor collapsed replication forks. Subunit: May self-associate. Interacts with MUS81. Interacts withERCC4 and FANCM. Subcellular Location: Nucleus, nucleolus. Note=Recruited toregions of DNA damage in S-phase cells. Similarity: 减数分裂内切酶EME1抗体Belongs to the EME1/MMS4 family. Database links: UniProtKB/Swiss-Prot: Q96AY2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
减数分裂内切酶EME1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 干细胞 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid