凝溶胶蛋白家族Fli-1/Flightless I抗体
规格：1mg/1ml
英文名： Flightless 1
别名： Fli 1; FLI; Fli1; Flightless-1; Flightless1; Flightless 1; Flightless I (Drosophila) homolog; Flightless I homolog; Flightless I homolog (Drosophila); Flightless1; FlightlessI; FLII; Fliih; FLIL; MGC3
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Flightle
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
凝溶胶蛋白家族Fli-1/Flightless I抗体产品介绍：background: This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene leads to abnormal muscle function, arrested development and embryonic lethality. The protein sequence shows that this might be a regulator of cytoskeleton and may have a role during cell division. Function: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. Subunit: Can form homodimers or heterodimers with ETV6/TEL1. Subcellular Location: Nucleus. DISEASE: Defects in FLI1 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms 凝溶胶蛋白家族Fli-1/Flightless I抗体that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain凝溶胶蛋白家族Fli-1/Flightless I抗体. Contains 1 PNT (pointed) domain. Database links: Entrez Gene: 2314 Human Entrez Gene: 14248 Mouse Entrez Gene: 287375 Rat Omim: 600362 Human SwissProt: Q13045 Human SwissProt: Q9JJ28 Mouse Unigene: 513984 Human Unigene: 339755 Mouse Unigene: 144698 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
凝溶胶蛋白家族Fli-1/Flightless I抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 干细胞 细胞周期蛋白 细胞分化 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid