细胞分裂周期蛋白8抗体
规格：1mg/1ml
英文名： CDCA8
别名： BOR; BOREA_HUMAN; Borealin; CDCA8; Cell division cycle associated 8; Cell division cycle-associated protein 8; Dasra B; Dasra-B; DasraB; FLJ10468; FLJ12042; hDasra-B; MESRGP; OTTHUMP; Pluri
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Borealin
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
细胞分裂周期蛋白8抗体产品介绍：background: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control 细胞分裂周期蛋白8抗体of attachment-error-correction and chromosome alignment. Subunit: May form homooligomers and homodimers. Subcellular Location: Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Post-translational modifications: Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3. Similarity: Belongs to the borealin family. Database links: UniProtKB/Swiss-Prot: Q53HL2.2 Entrez Gene: 55143 Human Entrez细胞分裂周期蛋白8抗体 Gene: 52276 Mouse Entrez Gene: 500545 Rat Omim: 609977 Human SwissProt: Q53HL2 Human SwissProt: Q8BHX3 Mouse SwissProt: Q6AXW0 Rat Unigene: 524571 Human Unigene: 28038 Mouse Unigene: 14970 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞分裂周期蛋白8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid