GSK3B相互作用蛋白抗体
规格：1mg/1ml
英文名： GSK3B interacting protein/Ninein
别名： Centrosome Marker; Centrosome Marker; Glycogen synthase kinase 3 beta interacting protein; Centrosome Marker; Glycogen synthase kinase 3 beta interacting protein; GSK3B interacting protein; h Glycogen
分子量： 243kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Ninein
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
GSK3B相互作用蛋白抗体产品介绍：background: Ninein is a centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells. It may also be a centrosome maturation factor and may be involved in microtubule nucleation. Ninein is a component of the core centrosome and is arranged in a tubular shape with an open and a closed end. Function: Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Subunit: Homooligomer. Interacts with GSK3B (GSK3-beta) via its C-terminus domain. Interacts with C14ORF166, such interaction may prevent GSK3B相互作用蛋白抗体its phosphorylation by GSK3-beta. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Tissue Specificity: Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5. Post-translational modifications: Phosphorylated by Aurora A (AIK) and PKA kinases but not CK2 or Aurora B (AIM). Phosphorylated upon DNA damage, probably by ATM or ATR. SimilarityGSK3B相互作用蛋白抗体 Contains 5 EF-hand domains. Database links: Entrez Gene: 51199 Human Entrez Gene: 18080 Mouse Omim: 608684 Human SwissProt: Q8N4C6 Human SwissProt: Q61043 Mouse Unigene: 310429 Human Unigene: 569387 Human Unigene: 244047 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GSK3B相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid