丝氨酸/苏氨酸蛋白激酶NEK1抗体
规格：1mg/1ml
英文名： NEK1
别名： NEK1; NEK1_HUMAN; Never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55; Renal carcinoma antigen NY-REN-
分子量： 143kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NEK1
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
丝氨酸/苏氨酸蛋白激酶NEK1抗体产品介绍：background: The protein encoded by this gene is a serine/threoninekinase involved in cell cycle regulation. The encoded protein isfound in a centrosomal complex with FEZ1, a neuronal protein thatplays a role in axonal development. Defects in this gene are acause of polycystic kidney disease (PKD). Several transcriptvariants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2010]. Function: Phosphorylates serines and threonines, but also appearsto possess tyrosine kinase activity. Implicated in the control ofmeiosis (By similarity). Involved in cilium assembly. Subunit: Binds to SPERT (By similarity). Subcellular Location: Nucleus (Probable). Cytoplasm, cytoskeleton,centrosome (By similarity). Note=Associated with the pericentriolarmaterial. Localizes to centrosome during interphase and mitosis (Bysimilarity). Tissue Specificity: High fetal expression in the brain and kidney. DISEASE丝氨酸/苏氨酸蛋白激酶NEK1抗体: Defects in NEK1 are the cause of short rib-polydactylysyndrome type 2 (SRPS2) [MIM:263520]. A lethal skeletal dysplasiacharacterized by markedly short ribs, short limbs, polydactyly, andmultiple anomalies including a narrow thorax with hypoplasticlungs, extreme polysyndactyly, dysproportionate dwarfism, mediancleft lip and palate, a ventriculoseptal defect and cystic kidneys.The radiographic hallmarks include shortened and horizontal ribs,squared scapulae and elevated clavicles with lateral kinking,normal spine and pelvis configuration, and shortening of the bonesof all four extremities, with extreme reduction of tibial bonelength. Similarity: Belongs to the protein kinase superfamily. NEK丝氨酸/苏氨酸蛋白激酶NEK1抗体 Ser/Thrprotein kinase family. NIMA subfamily. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: Q96PY6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸/苏氨酸蛋白激酶NEK1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid