缺陷性分配同源物β抗体
规格：1mg/1ml
英文名： PARD6B
别名： PAR 6 beta; Par 6 partitioning defective 6 homolog beta (C. elegans); PAR6B; PARD6 beta.
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PARD6B
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
缺陷性分配同源物β抗体产品介绍：background: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi protein complex. Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Subunit: Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42缺陷性分配同源物β抗体 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2. Subcellular Location: Cytoplasm. Cell membrane. Cell junction, tight junction. Tissue Specificity: Expressed in pancreas and in both ***** and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. Similarity: Belongs to the PAR6 family. Contains 1 OPR缺陷性分配同源物β抗体 domain. Contains 1 PDZ (DHR) domain. Contains 1 pseudo-CRIB domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
缺陷性分配同源物β抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 细胞分化 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid