PSF2蛋白抗体
规格：1mg/1ml
英文名： PSF2
别名： GINS complex subunit 2; GINS2; HSPC037; PSF2_HUMAN.
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PSF2
交叉反应：Human, Mouse, Rat, Dog, Pig,
细胞定位：细胞核
PSF2蛋白抗体产品介绍：background: The GINS complex is composed of four subunits, encoded by SLD5, PSF1, PSF2, and PSF3. In S. cerevisiae, it was first identified by genetic and biochemical methods to determine factors interacting with Sld5p. Genetic interactions between these four genes also suggest that they act together. The GINS complex was independently isolated in a large scale screen for cell cycle defects. A similar complex is found in Xenopus and has a ring-like structure. In yeast, all four genes are essential and cells defective in SLD5, PSF1, or PSF2 are impaired in their ability to replicate DNA. The complex localizes to origins of DNA replication and Sld5p was previously implicated as functioning in DNA replication due to its genetic interaction with DPB11. Additional genetic and biochemical interactions of the GINS complex with Dpb11p, Dpb2p, and Sld3p suggest that it functions in some way at the replication fork during DNA synthesis. Function: The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to PSF2蛋白抗体single-strandedDNA. Subunit: Component of the GINS complex which is a heterotetramerof GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex withGINS3. GINS complex interacts with DNA primase in vitro. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the GINS2/PSF2 family. Gene ID: 51659 Database links: Entrez Gene: 415824 Chicken Entrez Gene: 609436 Dog Entrez Gene: 51659 Human Entrez Gene: 272551 Mouse Entrez Gene: 292058 Rat Entrez Gene: 444053PSF2蛋白抗体 Xenopus laevis Entrez Gene: 554146 Zebrafish Omim: 610609 Human SwissProt: Q9Y248 Human SwissProt: Q9D600 Mouse SwissProt: Q7ZT46 Xenopus laevis Unigene: 433180 Human Unigene: 275910 Mouse Unigene: 3786 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产PSF2蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid